2008
2008-06-03
US Patent No. 7,381,818
Fluorescent probes containing 5'-minor groove binder, fluorophore and quenching moieties and methods of use thereof
2008-05-06
US Patent No. 7,368,549
Tm Leveling Compositions
2008-03-25
US Patent No. 7,348,146
Single nucleotide polymorphism analysis of highly polymorphic target sequences
2008-02-12
US Patent No. 7,329,501
Interalpha trypsin inhibitor biopolymer markers indicative of insulin resistance
2008-01-15
US Patent No. 7,319,022
Amplification methods
2008-01-01
US Patent No. 7,314,762
Apolipoprotein biopolymer markers indicative of insulin resistance
2008-01-01
US Patent No. 7,314,717
Biopolymer marker indicative of disease state having a molecular weight of 1562 daltons
2008-01-01
US Patent No. 7,314,708
Method and apparatus for electronic synthesis of molecular structures
2008-01-01
US Patent No. 7,314,542
Methods and materials for optimization of electronic transportation and hybridization reactions
2007
2007-11-27
US Patent No. 7,300,757
Electronic systems and component devices for macroscopic and microscopic molecular biological reaction, analyses, and diagnostics
2007-11-20
US Patent No. 7,297,495
Hybridization-triggered fluorescent detection of nucleic acids
2007-11-13
US Patent No. 7,294,688
Biopolymer marker indicative of disease state having a molecular weight of 1348 daltons
2007-09-18
US Patent No. 7,270,850
Mesoporous permeation layers for use on active electronic matrix devices
2007-09-11
US Patent No. 7,267,751
Programmable multiplexed active biologic array
2007-09-04
US Patent No. RE39,816
Conjunctive analysis of biological marker expression for predicting cardiac mortality
2007-08-14
US Patent No. 7,256,053
Diagnostic device for analyte detection
2007-08-07
US Patent No. 7,252,940
Abasic site endonuclease assay
2007-07-10
US Patent No. 7,241,419
Circuits for the control of output current in an electronic device for performing active biological operations
2007-04-17
US Patent No. 7,205,105
Real-time linear detection probes: sensitive 5'-minor groove binder-containing probes for PCR analysis
2007-03-06
US Patent No. 7,186,813
Biomolecules having multiple attachment moieties for binding to a substrate surface
2007-02-20
US Patent No. 7,179,605
Fibronectin precursor biopolymer markers indicative of Alzheimer's disease
2007-02-20
US Patent No. 7,179,606
IG heavy chain, IG kappa, IG lambda biopolymer markers predictive of Alzheimer's disease
2007-02-20
US Patent No. 7,179,610
Complement C3 precursor biopolymer markers indicative of insulin resistance
2007-02-06
US Patent No. 7,172,864
Methods for electronically-controlled enzymatic reactions
2007-02-06
US Patent No. 7,172,896
Integrated protable biological detection system
2006
2006-12-26
US Patent No. 7,153,955
Pentopyranosyl nucleic acid arrays, and uses thereof
2006-12-19
US Patent No. 7,150,997
Multiplexed active biologic array
2006-11-14
US Patent No. 7,135,283
Topoisomerase type II gene polymorphisms and their use in identifying drug resistance and pathogenic strains of microorganisms
2006-11-14
US Patent No. 7,135,297
Protein biopolymer markers indicative of insulin resistance
2006-11-07
US Patent No. 7,132,244
Betaine/GABA transport protein biopolymer marker indicative of insulin resistance
2006-10-31
US Patent No. 7,129,229
Hydrazide building blocks and hydrazide modified biomolecules
2006-10-24
US Patent No. 7,125,678
Protein biopolymer markers predictive of type II diabetes
2006-10-17
US Patent No. 7,122,327
Biopolymer markers indicative of type II diabetes
2006-09-26
US Patent No. 7,112,684
Compounds and methods for fluorescent labeling
2006-09-05
US Patent No. 7,101,680
Method for detecting the presence of monomeric brain associated human glutamine synthetase
2006-09-05
US Patent No. 7,101,661
Apparatus for active programmable matrix devices
2006-09-05
US Patent No. 7,101,717
Addressable biologic electrode array
2006-08-29
US Patent No. 7,097,989
Complement C4 precursor biopolymer markers predictive of type II diabetes
2006-08-22
US Patent No. 7,094,549
Fibronectin biopolymer marker indicative of insulin resistance
2006-08-08
US Patent No. 7,087,435
Biopolymer maker indicative of disease state having a molecular weight of 2753 daltons
2006-07-11
US Patent No. 7,074,576
Protein biopolymer markers indicative of Alzheimer's disease
2006-07-04
US Patent No. 7,070,945
Process for determining the presence of monomeric brain associated human glutamine synthetase in patients exhibiting mild cognitive impairment
2006-07-04
US Patent No. 7,070,961
Electronically mediated nucleic acid amplification in NASBA
2006-06-13
US Patent No. 7,060,224
Methods for electronic, homogeneous assembly and fabrication of devices
2006-05-29
US Patent No. 7,052,849
Protein biopolymer markers predictive of insulin resistance
2006-05-23
US Patent No. 7,049,397
Biopolymer marker indicative of disease state having a molecular weight of 1211 daltons
2006-05-16
US Patent No. 7,045,610
Modified oligonucleotides for mismatch discrimination
2006-05-16
US Patent No. 7,045,097
Biologic electrode array with integrated optical detector
2006-04-11
US Patent No. 7,026,129
IG lambda biopolymer markers predictive of Alzheimers disease
2006-03-21
US Patent No. 7,015,004
Inter-alpha trypsin inhibitor biopolymer marker indicative of insulin resistance
2006-03-21
US Patent No. 7,014,854
Method for retarding or precluding Alzheimer's dementia
2006-02-14
US Patent No. 6,998,243
Biopolymer marker indicative of disease state having a molecular weight of 1793 daltons
2006-01-24
US Patent No. 6,989,086
Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis
2005
2005-12-06
US Patent No. 7,972,339
Compounds and methods for fluorescent labeling
2005-12-06
US Patent No. 6,792,328
Non-aggregating non-quenching oligomer comprising nucleotide analogs
2005-11-08
US Patent No. 6,962,991
Process for the synthesis of pyrazolopyrimidine
2005-11-01
US Patent No. 6,960,298
Mesoporous permeation layers for use on active electronic matrix devices
2005-10-04
US Patent No. 6,951,930
Hybridization-triggered fluorescent detection of nucleic acids
2005-09-27
US Patent No. 6,949,367
Modified oligonucleotides for mismatch discrimination
2005-09-13
US Patent No. 6,942,778
Microstructure apparatus and method for separating differently charged molecules using an applied electric field
2005-06-28
US Patent No. 6,911,310
Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system
2005-05-17
US Patent No. 6,893,822
Enzymatic modification of a nucleic acid-synthetic binding unit conjugate
2005-05-10
US Patent No. 6,890,722
HP biopolymer markers predictive of insulin resistance
2005-05-10
US Patent No. 6,890,763
Biopolymer maker indicative of disease state having a molecular weight of 1350 daltons
2005-05-10
US Patent No. 6,891,154
Amino acid sequence pattern matching
2005-05-03
US Patent No. 6,887,362
Dielectrophoretic separation and immunoassay methods on active electronic matrix devices
2005-04-26
US Patent No. 6,884,584
Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders
2005-03-15
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Multiplexed active biologic array
2005-03-08
US Patent No. 6,864,071
Multiplex amplification and separation of nucleic acid sequences using ligation-dependant strand displacement amplification an bioelectronic chip technology
2005-01-04
US Patent No. 6,838,053
Platinum silicide permeation layer device with microlocaions
2004
2004-11-30
US Patent No. 6,824,740
Apparatus for active biological sample preparation
2004-11-23
US Patent No. 6,821,729
Devices for molecular biological analysis and diagnostics including waveguides
2004-09-14
US Patent No. 6,790,945
Fluorescent quenching detection reagents and methods
2004-08-24
US Patent No. 6,780,584
Electronic systems and component devices for macroscopic and microscopic molecular biological reactions, analyses and diagnostics
2004-06-22
US Patent No. 6,753,148
Methods and apparatus for detecting variants utilizing base stacking
2004-04-27
US Patent No. 6,726,880
Electronic device for performing active biological operations and method of using same
2004-04-27
US Patent No. 6,727,356
Fluorescent quenching detection reagents and methods
2004-03-16
US Patent No. 6,706,473
Systems and devices for photoelectronic transport and hybridization of oligonucleotides
2004-03-02
US Patent No. 6,699,978
Linker nucleoside, and production and use of the same
2004-03-02
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Fluorescent quenching detection reagents and methods
2004-02-24
US Patent No. 6,696,555
3'-Desoxypentopyranosyl nucleic acid, its production and its use
2004-02-10
US Patent No. 6,689,884
Supramolecular pairing system, its preparation and use
2004-02-03
US Patent No. RE38,416
Cross-linking oligonucleotides
2004-01-27
US Patent No. 6,682,936
Addressable biologic electrode array
2004-01-27
US Patent No. 6,683,173
Tm Leveling Methods
2003
2003-12-09
US Patent No. 6,660,845
Non-aggregating, non-quenching oligomers comprising nucleotide analogues; methods of synthesis and use thereof
2003-11-25
US Patent No. 6,652,808
Methods for the electronic assembly and fabrication of devices
2003-11-25
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Fluorescent quenching detection reagents and methods
2003-10-28
US Patent No. 6,638,482
Reconfigurable detection and analysis apparatus and method
2003-09-30
US Patent No. 6,626,417
Microfluidic valve and microactuator for a microvalve
2003-09-02
US Patent No. 6,613,894
Method for producing a pyranosyl nucleic acid conjugate
2003-08-19
US Patent No. 6,608,186
Pyranosyl nucleic acid conjugates
2003-07-08
US Patent No. 6,589,742
Multiplex amplification and separation of nucleic acid sequences on a bioelectronic microchip using asymmetric structures
2003-06-24
US Patent No. 6,582,660
Control system for active programmable electronic microbiology system
2003-05-27
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Method for the electronic assembly and fabrication of devices
2003-04-15
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Attachment of oligonucleotides to solid supports through schiff base type linkages for capture and detection of nucleic acids
2003-04-08
US Patent No. 6,545,134
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2003-04-01
US Patent No. 6,540,961
Multicomponent devices for molecular biological analysis and diagnostics
2003-03-11
US Patent No. 6,531,302
Anchored strand displacement amplification on an electronically addressable microchip
2003-02-25
US Patent No. 6,524,517
Methods for molding and grafting highly uniform polymer layers onto electronic microchips
2003-02-11
US Patent No. 6,518,022
Method for enhancing the hybridization efficiency of target nucleic acids using a self-addressable, self-assembling microelectronic device
2003-01-14
US Patent No. 6,506,896
Use of a pentopyranosyl nucleoside for producing an electronic component, and conjugates of said pentopyranosyl nucleoside
2002
2002-12-10
US Patent No. 6,492,346
Hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders
2002-12-10
US Patent No. 6,492,122
Quantitative analysis methods on active electronic microarrays
2002-12-03
US Patent No. 6,488,832
Array based electrophoretic system for the analysis of multiple biological samples
2002-11-26
US Patent No. 6,486,308
Covalently linked oligonucleotide minor groove binder conjugates
2002-11-26
US Patent No. 6,485,906
Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination
2002-10-29
US Patent No. 6,472,153
Hybridization-triggered fluorescent detection of nucleic acids
2002-10-22
US Patent No. 6,468,742
Methods for determination of single nucleic acid polymorphisms using bioelectronic microchip
2002-08-27
US Patent No. 6,441,159
Attachment of oligonucleotides to solid supports through schiff base type linkages for capture and detection of nucleic acids
2002-07-30
US Patent No. 6,426,408
Covalently linked oligonucleotide minor groove binder conjugates
2002-07-23
US Patent No. 6,423,271
Laminated assembly for active bioelectronic devices
2002-07-09
US Patent No. 6,416,953
Hybridization of polynucleotides conjugated with chromophores and fluorophoes to generate donor-to-donor energy transfer system
2002-06-11
US Patent No. 6,403,367
Integrated portable biological detection system
2002-05-28
US Patent No. 6,395,493
Methods and apparatus for determination of length polymorphisms in DNA
2002-05-07
US Patent No. 6,385,080
DNA optical storage device using forster energy transfer mechanism
2002-04-30
US Patent No. 6,379,897
Methods for gene expression monitoring on electronic microarrays
2002-04-23
US Patent No. 6,375,899
Electrophoretic buss for transport of charged materials in a multi-chamber system
2002-01-15
US Patent No. 6,339,147
Attachment of oligonucleotides to solid supports through schiff base type linkages for capture and detection of nucleic acids
2001
2001-12-18
US Patent No. 6,331,274
Advanced active circuits and devices for molecular biological analysis and diagnostics
2001-12-04
US Patent No. 6,326,173
Electronically Mediated Nucleic Acid Amplification in NASBA
2001-11-20
US Patent No. 6,319,472
System including functionally separated regions in electrophoretic system
2001-11-13
US Patent No. 6,315,953
Devices for molecular biological analysis and diagnostics including waveguides
2001-11-06
US Patent No. 6,312,894
Improved hybridization and mismatch discrimination using oligonucleotides conjugated to minor groove binders
2001-10-30
US Patent No. 6,309,602
Stacked, reconfigurable system for electrophoretic transport of charged materials
2001-10-30
US Patent No. 6,309,601
Scanning optical detection system
2001-10-30
US Patent No. 6,309,833
Multiplex amplification and separation of nucleic acid sequences on a bioelectronic microchip using asymmetric structures
2001-10-23
US Patent No. 6,306,348
Inorganic permeation layer for micro-electric device
2001-10-16
US Patent No. 6,303,082
Permeation layer attachment chemistry and method
2001-09-11
US Patent No. 6,287,517
Laminated assembly for active bioelectronic devices
2001-09-04
US Patent No. 6,284,117
Apparatus and method for removing small molecules and ions from Low Volume Biological Samples
2001-08-28
US Patent No. 6,280,590
Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis
2001-07-10
US Patent No. 6,258,606
Multiplexed active biologic array
2001-07-03
US Patent No. 6,254,827
Methods for fabricating multi-component devices for molecular biological analysis and diagnostics
2001-06-19
US Patent No. 6,249,784
System and method for searching and processing databases comprising named annotated text strings
2001-06-12
US Patent No. 6,245,508
Method for fingerprinting utilizing an electronically addressable array
2001-05-29
US Patent No. 6,238,624
Methods for transport in molecular biological analysis and diagnostics
2001-05-29
US Patent No. 6,238,868
Multiplex amplification and separation of nucleic acid sequences using ligation-dependant strand displacement amplification and bioelectronic chip technology
2001-05-01
US Patent No. 6,225,059
Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics
2001-03-27
US Patent No. 6,207,373
Methods for determining nature of repeat units In DNA
2000
2000-12-22
US Patent No. 6,162,603
Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system
2000-10-10
US Patent No. 6,129,828
Apparatus and methods for active biological sample preparation
2000-10-03
US Patent No. 6,127,121
Oligonucleotides containing pyrazolo[3,4-D]pyrimidines for hybridization and mismatch discrimination
2000-08-08
US Patent No. 6,099,803
Advanced active electronic devices for molecular biological analysis and diagnostics
2000-07-04
US Patent No. 6,084,102
Covalently linked oligonucleotide minor groove binder conjugates
2000-06-06
US Patent No. 6,071,394
Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis
2000-05-30
US Patent No. 6,068,818
Multicomponent devices for molecular biological analysis and diagnostics
2000-05-23
US Patent No. 6,067,246
Method for writing data to and reading multiple bit data words from a DNA optical storage device
2000-04-18
US Patent No. 6,051,380
Methods and procedures for molecular biological analysis and diagnostics
2000-04-11
US Patent No. 6,048,690
Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis
1999
1999-10-12
US Patent No. 5,965,452
Multiplexed active biologic array
1999-07-27
US Patent No. 5,929,208
Methods for electronic synthesis of polymers
1999-06-15
US Patent No. 5,912,340
Selective binding complementary oligonucleotides
1999-01-25
US Patent No. 6,017,696
Methods for electronic stringency control for molecular biological analysis and diagnostics
1999-01-11
US Patent No. 6,013,166
Method for reducing the linear dimension necessary for high resolution electrophoretic separation
1998
1998-12-15
US Patent No. 5,849,489
Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system
1998-12-15
US Patent No. 5,849,486
Methods for hybridization analysis utilizing electronically controlled hybridization
1998-11-10
US Patent No. 5,835,404
DNA optical storage device utilizing non-radiative energy transfer
1998-09-01
US Patent No. 5,801,155
Oligonucleotide minor groove binder conjugates
1998-07-28
US Patent No. 5,787,032
Deoxyribonucleic acid (DNA) optical storage using non-radiative energy transfer between a donor group, an acceptor group and a quencher group
1997
1997-05-27
US Patent No. 5,632,957
Molecular biological diagnostic systems including electrodes
1997-02-25
US Patent No. 5,605,662
Active programmable electronic devices for molecular biological analysis and diagnostics
1996
1996-10-15
US Patent No. 5,565,322
Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to-donor energy transfer system
1996-07-02
US Patent No. 5,532,129
Self-organizing molecular photonic structures based on chromophore and fluorophore containing polynucleotides and methods of their use
1996-04-29
US Patent No. 5,512,667
Trifunctional intermediates for preparing 3'-tailed oligonucleotides
1995
1995-05-30
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Solid support for synthesis of 3'-tailed oligonucleotides